Yes, it can.

A pharmacist explains that coffee (especially the caffeine) can affect how your medicine works.

Here’s what to know:

Caffeine can block medicine. Some meds need to travel through your body to your brain. Caffeine uses the same path, so they compete. It can make side effects worse. You might feel more jittery, shaky, or anxious. It may slow down or speed up meds. That means your medicine might not work like it should—or wear off too soon.

What to do:

Don’t take medicine with coffee. Wait at least an hour after taking pills before drinking it. Ask your doctor or pharmacist about coffee and your specific meds. Watch how you feel. If something seems off, it could be the caffeine.

Bottom line: Coffee isn’t always a problem, but the timing matters.

https://pmc.ncbi.nlm.nih.gov/articles/PMC8101832/#:%7E:text=Table%20I.&text=The%20next%20stage%20of%20hypertension,response%20to%20calcium%20channel%20blockers.&text=The%20potential%20for%20caffeine%20to,Table%20II%20summarizes%20these%20recommendations.